Tyrosine Hydroxylase Monoclonal Antibody (185) (MA1-24654) (2024)


Tyrosine Hydroxylase Monoclonal Antibody (185) (MA1-24654) (1)

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  • Primary Antibodies
  • Tyrosine Hydroxylase Antibodies


Advanced Verification

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.

1 Published Figure
10 References

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Tyrosine Hydroxylase Monoclonal Antibody (185) (MA1-24654) (3)

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Tyrosine Hydroxylase Antibody (MA1-24654) in ICC/IF

Immunofluorescence analysis of Tyrosine Hydroxylase using of Tyrosine Hydroxylase using Tyrosine Hydroxylase Monoclonal Antibody (185) (Product # MA1-24654) was performed using 70% confluent log phase PC-12 cells treated with 5 µg/mL dexamethasone for 6 days. The cells were fixed with 4% Paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 10 min... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more



Tyrosine Hydroxylase Monoclonal Antibody (185) (MA1-24654) (4)

Tyrosine Hydroxylase Monoclonal Antibody (185) (MA1-24654) (5)

Tyrosine Hydroxylase Monoclonal Antibody (185) (MA1-24654) (6)

Tyrosine Hydroxylase Monoclonal Antibody (185) (MA1-24654) (7)

Tyrosine Hydroxylase Monoclonal Antibody (185) (MA1-24654) (8)

Tyrosine Hydroxylase Monoclonal Antibody (185) (MA1-24654) (9)

Tyrosine Hydroxylase Monoclonal Antibody (185) (MA1-24654) (10)

Tyrosine Hydroxylase Monoclonal Antibody (185) (MA1-24654) (11)

Product Details



Tested Dilution


Western Blot(WB)



Immunohistochemistry (IHC)


View 8 publications8 publications

Immunohistochemistry (Paraffin) (IHC (P))



Immunohistochemistry (Frozen)(IHC (F))





View 2 publications2 publications

Product Specifications

Species Reactivity


Published species



Mouse/ IgG2a








Recombinant protein corresponding to the C-terminal portion of mouse Tyrosine Hydroxylase.






0.24 mg/mL

Storage buffer

tissue culture supernatant


15mM sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice



Product Specific Information

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.


Protein Aliases:dystonia 14; EC; HGNC:11782; TH; TH isoform 3; TH isoform a; TH-4; TY3H; TYH antibody; Tyrosine 3-hydroxylase; Tyrosine 3-monooxygenase

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Gene Aliases:DYT14; DYT5b; TH; The; TYH

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response to hypoxiasynaptic transmission, dopaminergicdopamine biosynthetic process from tyrosineheart developmentvisual perceptionlearningmemorymating behaviorlocomotory behaviorregulation of heart contractionaromatic amino acid family metabolic processorgan morphogenesisaminergic neurotransmitter loading into synaptic vesicleneurotransmitter biosynthetic processdopamine biosynthetic processepinephrine biosynthetic processnorepinephrine biosynthetic processcatecholamine biosynthetic processeye photoreceptor cell developmenteating behaviorresponse to ethanolembryonic camera-type eye morphogenesisoxidation-reduction processresponse to amphetamineheart morphogenesisfatty acid metabolic processsphingolipid metabolic processsensory perception of soundresponse to water deprivationresponse to light stimulusresponse to herbicideresponse to salt stressanatomical structure morphogenesisresponse to zinc ionmulticellular organism agingresponse to activityglycoside metabolic processphthalate metabolic processcerebral cortex developmentresponse to nutrient levelsresponse to estradiolresponse to lipopolysaccharideisoquinoline alkaloid metabolic processsocial behaviorcellular response to drugresponse to isolation stressresponse to immobilization stressterpene metabolic processcircadian sleep/wake cycleresponse to peptide hormonepigmentationresponse to etherresponse to pyrethroidresponse to corticosteroneresponse to electrical stimulusphytoalexin metabolic processcellular response to manganese ioncellular response to nicotinecellular response to glucose stimuluscellular response to growth factor stimulusresponse to metal ionresponse to organic cyclic compoundresponse to insecticideresponse to nicotineresponse to drugresponse to steroid hormonecognitionprotein hom*otetramerizationresponse to growth factorcellular response to alkaloid


tyrosine 3-monooxygenase activityprotein bindingferrous iron bindingferric iron bindingamino acid bindingoxygen bindingenzyme bindingprotein domain specific bindingtetrahydrobiopterin bindingdopamine bindingmonooxygenase activityiron ion bindingoxidoreductase activityoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygenmetal ion binding

It has to be done as per old AB suggested Products section.

Tyrosine Hydroxylase Monoclonal Antibody (185) (MA1-24654) (12)

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Tyrosine Hydroxylase Monoclonal Antibody (185) (MA1-24654) (13)

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Tyrosine Hydroxylase Monoclonal Antibody (185) (MA1-24654) (2024)


What disease is diagnosed with monoclonal antibodies? ›

This can make disease identification much easier as the coloured cells can easily be seen with a microscope. Monoclonal antibodies are very useful as a diagnostic test because: they can detect very small amounts of pathogens in a sample, and. they are very specific to a particular antigen and so the test is reliable.

What does the tyrosine hydroxylase do? ›

Tyrosine hydroxylase is the rate-limiting enzyme of catecholamine biosynthesis; it uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to DOPA. Its amino terminal 150 amino acids comprise a domain whose structure is involved in regulating the enzyme's activity.

What increases tyrosine hydroxylase? ›

Hormones (e.g. glucocorticoids), drugs (e.g. cocaine), or second messengers such as cAMP increase tyrosine hydroxylase transcription.

What does tyrosine hydroxylase stain for? ›

Tyrosine hydroxylase (TH) is a marker for dopamine, norepinephrine, and epinephrine-containing (catecholamine) neurons and endocrine cells.

What autoimmune disease does monoclonal antibodies treat? ›

Monoclonal antibodies are a class of drugs used to treat inflammatory autoimmune disorders (conditions in which the immune system attacks the healthy parts of the body and causes pain, swelling, and damage), skin disorders, certain types of arthritis (such as rheumatoid arthritis, psoriatic arthritis, juvenile ...

What is the major problem with monoclonal antibodies? ›

Some monoclonal antibodies are associated with a higher risk of inflammatory lung disease. Skin problems. Sores and rashes on your skin can lead to serious infections in some cases. Serious sores can also occur on the tissue that lines your cheeks and gums (mucosa).

What are the symptoms of tyrosine hydroxylase? ›

The severe form of the disease will appear in infancy, usually before six months of age. Affected infants have delayed motor skills, weakness in the chest and abdomen, stiffness in the arms and legs, and tremor. Many infants with the disease will have trouble controlling eye movements.

What are the symptoms of tyrosine deficiency in adults? ›

Disease Overview

Tyrosine hydroxylase deficiency (THD) is a rare genetic disorder characterized by a wide spectrum of symptoms. These symptoms can vary widely in people who are affected, and even among members of the same family. Common symptoms include an uncoordinated manner of walking (abnormal gait) and dystonia.

What happens if you are deficient in tyrosine? ›

It is involved in the structure of almost every protein in the body. It's rare to be deficient in tyrosine. Low levels have been associated with low blood pressure, low body temperature, and an underactive thyroid. This does not mean, however, that taking tyrosine supplements will help any of these conditions.

What does tyrosine do in the brain? ›

May help in stressful situations

In one example, participants who performed a test that measured their cognitive flexibility did better when taking an L-tyrosine supplement versus a placebo. Another study shows that people who worked on a mentally demanding task saw their working memory improve while taking L-tyrosine.

What hormone does tyrosine produce? ›

Tyrosine is an amino acid (protein-building block) that the body synthesizes from phenylalanine. This is another amino acid. It helps make neurotransmitters, such as dopamine, norepinephrine, and epinephrine. It helps make thyroid hormones, such as thyroxine.

What does tyrosine hydroxylase do in the brain? ›

Tyrosine hydroxylase takes part in the first step of the pathway that produces a group of chemical messengers called catecholamines. Catecholamines are involved in the autonomic nervous system, which controls involuntary processes such as the regulation of blood pressure and body temperature.

What is the significance of tyrosine? ›

Tyrosine is one of the 20 standard amino acids present in the body and used by cells to synthesize proteins. This is a non-essential amino acid, meaning that when it is not only ingested from diet, it is also synthesized by the body.

Why is tyrosine in urine? ›

Tyrosine is occasionally found in the urine in cases of cystinuria. tyrosinuria may also occur independently of any anomaly of metabolism. The substance has been recovered in crystalline form from the urine of a normal subject3 and in various pathologic conditions, mainly involving the liver and biliary passages.

What conditions are monoclonal antibodies used for? ›

Monoclonal antibodies are routinely used in several fields but the great challenge has been their use as therapeutic agents for the treatment of diseases, such as breast cancer, leukemia, asthma, macular degeneration, arthritis, Crohn's disease, and transplants, among others.

Which disease is treated with therapeutic monoclonal antibodies? ›

Monoclonal antibodies have been used to treat the following conditions: Cancer. Organ transplant rejection. Inflammatory and autoimmune disorders, including allergies.

What can monoclonal antibodies help detect? ›

An immunoassay uses monoclonal antibodies to diagnose infections such as HIV close HIVHuman Immunodeficiency Virus, a disease which damages cells in the immune system., malaria and chlamydia. This can make disease identification much easier.


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