1. Structural insights into the mechanism of GTP initiation of microtubule ...
25 sep 2023 · Here, we present cryo-EM structures of tubulin heterodimer at their GTP- and GDP-bound states, intermediate assembly states of GTP-tubulin, and ...
In eukaryotes, the dynamic assembly of microtubules (MT) plays an important role in numerous cellular processes. The underlying mechanism of GTP triggering MT assembly is still unknown. Here, we present cryo-EM structures of tubulin heterodimer at their GTP- and GDP-bound states, intermediate assembly states of GTP-tubulin, and final assembly stages of MT. Both GTP- and GDP-tubulin heterodimers adopt similar curved conformations with subtle flexibility differences. In head-to-tail oligomers of tubulin heterodimers, the inter-dimer interface of GDP-tubulin exhibits greater flexibility, particularly in tangential bending. Cryo-EM of the intermediate assembly states reveals two types of tubulin lateral contacts, “Tube-bond” and “MT-bond”. Further, molecular dynamics (MD) simulations show that GTP triggers lateral contact formation in MT assembly in multiple sequential steps, gradually straightening the curved tubulin heterodimers. Therefore, we propose a flexible model of GTP-initiated MT assembly, including the formation of longitudinal and lateral contacts, to explain the nucleation and assembly of MT. In this study the authors explore the enigma of GTP-triggered microtubule assembly. The proposed flexible model emphasizes longitudinal and lateral contacts, enhancing our understanding of microtubule nucleation and assembly.
2. [PDF] State budget borrowing requirements' financing plan and its background
29 mrt 2023 · In the final quarter of 2022 GDP declined by. 2.4% (qoq, sa) after a 1% growth in the previ- ous quarter. Household consumption was.
3. Structural insights of the elongation factor EF-Tu complexes in protein ...
3 okt 2022 · Here, we report the crystal structures of Mtb EF-Tu•EF-Ts and EF-Tu•GDP complexes, showing the molecular basis of EF-Tu's representative ...
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is the second-deadliest infectious disease worldwide. Emerging evidence shows that the elongation factor EF-Tu could be an excellent target for treating Mtb infection. Here, we report the crystal ...
4. GDP and spending - Gross domestic product (GDP) - OECD Data
Bevat niet: e155 | Resultaten tonen met:e155
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5. Predictive Analytics in Focus - Moody's Events
E155. Debt Isn't Everything. 01:20:33. E154. Jobs Survey Smackdown! 48:38. E153 ... Gangbuster GDP. 48:38. E134. Bonds, Baseball and Blankies. 01:21:39. E133.
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6. Is GDP the wrong yardstick for measuring prosperity? - WABE
Gross domestic product, the total dollar value of goods and services sold in the U.S., has become fundamental to American economic policy.
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7. [PDF] Long-term Growth Model Natural Resource Extension (LTGM-NR)
8 mrt 2022 · ... E155]. Part 5: Set paths for exogenous variables: Natural ... Choose GDP Per Capita Annual growth rate from the dropdown menu in Cell A38.
8. Trend of Mortality Due to Congenital Anomalies in Children Younger ...
3 jun 2024 · Objective: We conducted this study to understand the death burden and trend of under-5 CA mortality (CAMR) in Zhejiang, one of the provinces ...
Background: As one of the leading causes of child mortality, deaths due to congenital anomalies (CAs) have been a prominent obstacle to meet Sustainable Development Goal 3.2. Objective: We conducted this study to understand the death burden and trend of under-5 CA mortality (CAMR) in Zhejiang, one of the provinces with the best medical services and public health foundations in Eastern China. Methods: We used data retrieved from the under-5 mortality surveillance system in Zhejiang from 2012 to 2021. CAMR by sex, residence, and age group for each year was calculated and standardized according to 2020 National Population Census sex- and residence-specific live birth data in China. Poisson regression models were used to estimate the annual average change rate (AACR) of CAMR and to obtain the rate ratio between subgroups after adjusting for sex, residence, and age group when appropriate. Results: From 2012 to 2021, a total of 1753 children died from CAs, and the standardized CAMR declined from 121.2 to 62.6 per 100,000 live births with an AACR of –9% (95% CI –10.7% to –7.2%; P<.001). The declining trend was also observed in female and male children, urban and rural children, and neonates and older infants, and the AACRs were –9.7%, –8.5%, –8.5%, –9.2%, –12%, and –6.3%, respectively (all P<.001). However, no significant reduction was observed in children aged 1-4 years (P=.22). Generally, the CAMR rate ratios for male versus female children, rural versus urban children, olde...
9. Channel 11: Good Times Bad Times - DoubleLine
4 mrt 2024 · Shinoda concludes with a review of economist forecasts for inflation and GDP ... Using Fed Funds Probabilities – with a Grain of Salt (E155).
DoubleLine Portfolio Manager Ken Shinoda takes a look at the state of the markets and macro issues in his recap of February in addition to the economic outlook going forward, a potentially mixed bag summed up by the title of Led Zeppelin’s 1969 song “Good Times Bad Times.” He begins with a look at fixed […]
10. Passive Smoking Indicators in Italy: Does the Gross Domestic Product ...
18 sep 2018 · 2016;25:e146–e155. doi: 10.1136/tobaccocontrol-2015-052828. [PubMed] [CrossRef] [Google Scholar]. 34. King B.A., Homa D.M., Dube S.R., Babb ...
Background: The aim of this study is to analyse the correlation between regional values of Gross Domestic Product (GDP) and passive smoking in Italy. Methods: The outcome measures were smoking ban respect in public places, workplaces and at home, derived ...
11. [PDF] GOVERNOR'S ANNUAL MONETARY POLICY STATEMENT ADDRESS
2011 and 2012 GDP numbers are CSO's provisional estimates whilst 2013 and 2014 GDP ... guaranteed debt amounting to E155 million in 2014 against drawdowns of E ...
12. A national stratification of the global macroeconomic burden of central ...
21 okt 2022 · nomic data in the form of gross domestic product (GDP) and GDP per ... 2020; 22(2): E147-E155. 27. Robinson LA, Hammitt JK, O'Keeffe L ...
13. [PDF] CONGRESSIONAL RECORD— Extensions of Remarks E155 HON ...
E155. February 7, 2020 participation on many committees, task forces, ... D.C. has a higher per capita per- sonal income and gross domestic product than.
14. [PDF] Is governance, gross domestic product, inequality, population size or ...
2 nov 2017 · index.; GDP, gross domestic product; SII, slope index of inequality ... Pediatrics 2014;134:e155. 1–e1559. 12. Lin RT, Chien LC, Chen YM, et ...
