Characterization of melanin isolated from a dark septate endophyte (DSE), Exophiala pisciphila | Semantic Scholar (2024)

Inhibition studies involving specific inhibitors, both tricyclazole and phthalide, and suggest that fungal melanin could be synthesized through the 1,8-dihydroxynaphthalene pathway.

The present study demonstrates that melanin from Phoma sp.

The results suggest that melanin production is not an important functional trait that contributes to Cd and Zn tolerance, but might contribute toCd accumulation.

To enhance melanin production, a response surface methodology (RSM) was employed, specifically utilizing the central composite design (CCD), which increased the production rate of melanin increased by 62%, resulting in a yield of 28.3 mg/100 mL, which is comparatively higher than the actual yield.

The inherent properties of fungal melanin suggest its promising potential as a biomaterial for environmental applications and provided further evidence for the DHN-nature of E. mesophila melanin.

Melanin may play pivotal role in physiology of E. nigricans protecting it against UV radiation and dessication, and may be considered as a promising source of natural melanin.

Ustilago maydis can accumulate melanin in the cytosol without adverse physiological effects and this presents biotechnological potential for dye removal.

Results suggested that melanin played a protective role for E. pisciphila against Cd stress, but inhibition of melanin synthesis by tricyclazole did not have a remarkable impact on Cd accumulation in the fungus.

Melanin produced from fungi has significant biological activities that encourage its usage as a supportive medical route and is attributed to the possibility of using gamma rays as a safe method in small economic doses to stimulate melanin production from the fungi that have been isolated.

The Cryptococcus extract exhibited killer toxin activity against the pathogenic yeast Candida albicans and was evaluated as a potent bioactive molecule with bioactivity like antimicrobial, antioxidant, anti-inflammatory, and anticancer activity that describes the therapeutic nature of the extracted melanin pigment.

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This is the first report on characterization of melanin obtained from Pleurotuscystidiosus var.

It is found that melanin protects S. schenckii against certain oxidative antimicrobial compounds and against attack by macrophages.

Melanin in the hyphae of P. capitalensis may be responsible for the success of this fungus as a cosmopolitan endophyte, since melanin is known to enhance the survival capability of fungi in stressful environments.

The objective of this study was to examine the role of melanin in the interaction between the mycoparasite Microsphaeropsis ochracea and the apple scab pathogen Venturia inaequalis, and a reddish-brown pigment was obtained due to the accumulation of shunt products of the DHN melanin pathway instead of a dark- brown pigment, suggesting that the melanin extracted from V inae Qualis was a DHN pigment.

It appears that melanization of hyphae may afford protection to some marine fungi against sudden changes in osmotic pressure.

The results suggest that the melanin from A. nidulans is a potential HOCl scavenger and may be considered a promising material for the cosmetic industry for the formulation of creams that protect the skin against possible oxidative damage.

The results suggest that supplemental tricyclazole reduces the production of DHN-melanin, which may lead to a reduction in the inhibition of erythrose reductase and a higher yield of ERYthritol.

The melanin derived from ferment broth of Streptomyces G-HD-4 was isolated and purified by acid deposition,alkaline extraction,acid hydrobysis and multiplicate organic solvents extraction, and their physical and chemical properties revealed that the melanin had a favorable stability.

It is shown that melanin in Curvularia lunata is produced by a pentaketide pathway from 1,8-dihydroxynaphthalene, and the predicted amino acid sequence of the 28.6-kDa protein demonstrated hom*ology to other fungal 3HNR and other members of the short-chain dehydrogenase super family.

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